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Injection site rotation Rotate between at least three injection sites: the abdomen (2 or more inches from the navel), the front of the thigh, and the back of the upper arm

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Since skin cells take approximately 28 to 40 days to turn over, visible results such as increased brightness or a more even tone typically take between 8 and 12 weeks of consistent use

The real-world setting enhances the generalizability to clinical practice [14], where patients often have comorbidities and concomitant medications that would exclude them from clinical trials

Within this framework, semaglutide is best considered an add-on therapy rather than a replacement for established treatments

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