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It has been proposed that the circulating peptide could access the brain via the ARC and exert its anorectic actions through indirect activation of pro-opiomelanocortin (POMC) neurons in the hypothalamus and through the blocking of fasting ghrelin levels

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RNA sequencing analysis revealed that palbociclib treatment induces features previously reported in senescence cells 40 , with top upregulated Enricher terms being senescence and autophagy, cytokines and inflammatory response, PI3K-AKT-mTOR survival pathway and TGF-beta regulation of extracellular matrix (Fig

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