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Free radicals, characterized by one or more unpaired electrons, exhibit high reactivity, and their generation in biological systems predominantly involves oxygen and nitrogen species, including hydrogen peroxide (HO), organic hydroperoxides, nitric oxide, superoxide, and hydroxyl radicals 45

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These products can be effective for surface-level improvements but don't address deeper tissue changes

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Transcription factors such as Twist , Snail , and ZEB2 , which are directly regulated by hypoxia, play major roles in this process and share a frequent promoter: the HRE