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Both peptides ship lyophilized and are reconstituted before use, most commonly with bacteriostatic water, and both should be stored cold and protected from repeated freeze-thaw cycles

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After an initial loading phase of six injections over two weeks (or more frequently if neurological symptoms are present), maintenance injections are given every two to three months for life to prevent deficiency recurrence

Calcium-dependent NOX5 nicotinamide adenine dinucleotide phosphate oxidase contributes to vascular oxidative stress in human coronary artery disease

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The specific mechanisms are as follows