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have demonstrated that the microtubule-associated Rho guanine nucleotide exchange factor (GEF-H1) mediates TRPC3-dependent RhoA activation during mechanical stress, facilitating TGF--induced cardiac fibroblast-to-myofibroblast transition[191] (Figure 1)

Therefore, our -EC production process using immobilized NsPCS can be performed at much lower cost and higher productivity rates with higher volumetric efficiency than current chemical production

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