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Keywords: chondrocyte, senescence, autologous chondrocyte implantation, senolytic, FOXO4-DRI Introduction Autologous chondrocyte implantation (ACI) is a biomedical treatment that repairs cartilage injury in the knee joint, which has been shown to reduce pain and facilitate mobility recovery (Kreuz et al., 2019)

Neeland IJ et al

With insulin treatment, IGF-1 levels rose to the normal range and IGF-1 normalization depended on diabetes control and the route of insulin infusion

Cold therapy causes non-shivering thermogenesis, which means fat is used as fuel to make heat

1 It can further cause megaloblastic anemia which is when there is a presence of large red blood cell precursors in the bone marrow

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