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other children with severe cases may not be able to speak or use the toilet without help

*Correspondence: Yan-Ru Liu, [email protected]

doi: 10.1038/s41579-022-00722-z 183 MartinezS

doi: 10.1007/978-3-319-22822-8_15 488 RichmanSMorrisMCBroderickGCraddockTJAKlimasNGFletcherMA

Both preclinical (in vitro and in vivo) and clinical studies were considered for inclusion to provide a broad perspective on the current state of evidence

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