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507 Loss-of-function mutations in CBL are also linked to autoreactive inflammatory disorders, further implicating the UPS in MS pathogenesis

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These activated fibroblasts also drive chronic persistent inflammation via the secretion and expression of pro-angiogenic and pro-inflammatory cytokines and chemokines [9], which promote the recruitment of inflammatory immune cells [10]

In some cases, it may also be used off-label to manage blood sugar levels in type 2 diabetes, although this should be discussed with a healthcare provider

Drug holidays: Anecdotal reports suggest that taking a few weeks or months off the medication before recommencing can help reduce the impact of cessation and keep body weight stable