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This medication works through a dual action: GIP boosts insulin production and directly impacts fat metabolism, while GLP-1 reduces appetite and improves blood sugar regulation

In 2025, HQ is often prescribed in short cycles (812 weeks) and followed by maintenance treatments

These changes are associated with increased cardiovascular and metabolic disease risk

Its ability to modulate the immune response makes it a valuable tool in managing both acute and chronic inflammatory conditions

However, semaglutide's proven cardiovascular benefit, oral option, and years of real-world experience make it the more established choice for many patients today

If you reach a plateau despite adherence, your provider may consider dose adjustment, introduction of a second peptide therapy (such as tirzepatide), or reassessment of nutrition and exercise