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The trial endpoints include both traditional AD outcomes (e.g., cognition, brain imaging, AD fluid biomarkers) and gold standard aging measures (e.g., frailty, physical function, epigenetic age, etc.)

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Ideal chelating agents should exhibit a higher affinity for the metal toxicant being chelated, exhibit low toxicity itself, possess rapid excretion and through metal toxicant elimination, be ideally water soluble, cell membrane permeable, use an oral route of administration, undergo minimal metabolism and possess the ability to chelate with naturally occurring chelating groups in the biological system concerned

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