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GLP-1 signaling reduces appetite and modulates reward, while GIP signaling enhances metabolic regulation and may have central nervous system effects

A growing body of research suggests GLP-1s can help reverse fertility issues caused by obesity, including in women with PCOS/PMOS

In addition to alterations in the mechanistic functions of brain endothelial cells, BBB breakdown is evident by degeneration of both endothelial cells and pericytes [101]

Bauman et al., 2008)

Gastrointestinal symptoms are the most frequently reported adverse effects and may include: Nausea and vomiting often severe and persistent, potentially leading to dehydration and, in some cases, acute kidney injury (particularly if you have existing kidney problems) Abdominal pain or discomfort ranging from mild cramping to significant pain Diarrhoea which may be frequent and watery Loss of appetite more pronounced than usual Bloating and indigestion due to delayed gastric emptying Hypoglycaemia (low blood sugar) is another concern, particularly if you are taking other diabetes medications such as insulin or sulphonylureas

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