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Kesika et al., 2021)

Acetaminophen also increases both neuronal CYP2E1 enzymatic activity and protein levels, as determined by western blot, leading to neuronal death through mitochondrial-mediated mechanisms that involve cytochrome c release and caspase 3 activation

doi: 186

Brain and wakefulness Histamine is also a neurotransmitter involved in arousal, sleep-wake regulation, attention, appetite, memory and modulation of other neurotransmitter systems

FIGURE 1 Ferroptosis appears to require the presence of specific highly oxidisable phosphatidylethanolamine phospholipids containing the polyunsaturated fatty acids (PUFAs) arachidonic acid and adrenic acid