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Signal transduction, redox homeostasis, cell-to-cell contact and secreted factors present in the TME can prompt differentiated tumor cells to reacquire stem cell-like characteristics

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It is a popular research tool for investigating targeted weight management, metabolic health, and adipose tissue regulation

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Semin Immunol (2006) 18(4):20713

Thus, glutathione depletion triggers death consistent with ferroptosis in BT-549 cells and identifies lipid hydroperoxides as the lethal ROS species underlying glutathione addiction in these cells