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Clinical trials in Alzheimers disease Alzheimers disease is where the 2025 data forced the largest revision, and where the contrast between observational promise and trial outcome is sharpest

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doi: 10.1269/jrr.07032 53 KimJ

Notably, this stage exhibits peak levels of CYP3A4, a major enzyme responsible for metabolizing 3050% of clinically administered drugs 22,23

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