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To make the comparison fair, patients were carefully matched based on age, body mass index, and baseline blood sugar levels

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147 Leptin binds to the leptin receptor (LepRb) and activates JAK2/STAT3 pathway to decrease body weight and normalizes blood glucose concentration, meanwhile, JAK2 stimulates the phosphorylation of insulin receptor substrate (IRS1/2), then activates PI3K/Akt pathway and directly affect insulin action

There are also strategic partnerships and a growing set of products that help drive market expansion

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