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REDEFINE1 (Phase 3): Over 3,400 adults with obesity or overweight (no T2DM) lost 22.7% of baseline body weight after 68 weeks, versus 12% with cagrilintide alone, 16% with semaglutide alone, and 2.3% on placebo

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In some embodiments, the otic formulation or composition comprises between about 0.01% to about 3% by weight of the povidone

Acyl-GIP abolished the avoidance effect of PYY in control GIPR AP-GFP animals but not in GIPR AP-KO animals (Fig