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Furthermore, clinical manifestations of withdrawal, such as dysphoria and irritability, mirror neurobiological adaptive mechanisms that involve greater stress sensitivity and hyperactivation of the hypothalamic-pituitary-adrenal axis, which could account for the increase in BDNF levels [38, 39]

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The paired effects on gastric emptying create more profound and prolonged satiety than either peptide alone

chelation by EDTA (100 M) abolishes copper coordination and reduces biological activity 8590% in fibroblast collagen synthesis assays confirming copper complexation is essential