Side effects Semaglutide also induces gastrointestinal disturbance, although pooled analysis of SUSTAIN 1-5 found comparable safety profiles in older and younger adults [98]
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Materials and methods: In the COMBINE trials, adults with type 2 diabetes (T2D) were randomised 1:1 to IcoSema or once-weekly icodec (COMBINE 1), once-weekly semaglutide 1.0 mg (COMBINE 2), or basal-bolus therapy (insulin glargine U100 + insulin aspart
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