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For method 2 sample preparation, the initial sample preparation was the same as described for method 1, except that NEM was added to the extraction solvent (50 L of 50 mM NEM in 80% methanol, 20% 10 mM ammonium formate, pH 7.0 and 50 L of 100% ACN)

A large proportion of these studies reported on the impact of GLP-1RAs on dopaminergic neurotransmission responsible for reward processingwhich could contribute to their efficacy as anti-obesity medications by means of a reduction of food-related incentive 110

Given the incremental complexity of the tested models, in the following sections, we start by describing the core reference U-Net architecture (Sect

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