It has no plasma pharmacokinetic endpoints
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For good reason: while high levels of folic acid have health risks of their own, low levels of vitamin B9 have been associated with cancer, stroke, heart disease, and birth defects
Study Design The study focused on 27 dogs from the ASPCAs Animal Recovery Center (ARC) and Canine Annex for Rehabilitation and Enrichment (CARE) that were emaciated because of chronic malnutrition
Common side effects include: Gastrointestinal symptoms (nausea, vomiting, diarrhea, constipation) Decreased appetite and potential malnutrition in vulnerable individuals Risk of hypoglycemia when combined with insulin or sulfonylureas Rare but serious risks including pancreatitis and gallbladder disease Important safety considerations include: Boxed warning for thyroid C-cell tumors in rodents
Many patients find success with five to six small meals throughout the day