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Who should be cautious: People with liver concerns or those taking multiple medications may wish to discuss use due to milk thistle extract and alpha lipoic acid

It is partially metabolized

Open questions What are the therapeutic targets or strategies suitable for the various diabetic complications

A wide range of non-motor manifestations, including hyposmia or anosmia, gastrointestinal disturbances like chronic constipation, rapid eye movement (REM) sleep behavior disorder, autonomic dysfunction, mood changes like depression and anxiety, and progressive cognitive impairment, account for a significant portion of the disease burden [3]

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It alleviates hepatic injury by activating the Nrf2/HO-1 antioxidant pathway and suppressing NF-Bmediated inflammation, highlighting its potential as a therapeutic applicant for ALD (94)