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The balance between diketone and keto-enol forms is strongly influenced by temperature, pH, and solvent polarity (77), and the enol-to-keto ratio is a significant determinant of curcumins pharmacological properties (78)

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Kang S, Brange J, Burch A et al (1991) Subcutaneous insulin absorption explained by insulins physicochemical properties: evidence from absorption studies of soluble human insulin and insulin analogues in humans