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Because this approach works by enhancing normal physiology rather than strong receptor activation, the effects tend to be more modest, vary from person to person and depend more heavily on diet and lifestyle

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Despite this, a substantial body of pre-clinical and limited clinical research has mapped DSIPs pharmacological effects across multiple systems, identifying several probable mechanistic axes including NMDA receptor modulation, adrenergic system regulation, MAPK/ERK cascade interaction, and mitochondrial respiration effects while acknowledging that the existence of an undiscovered DSIP-like endogenous peptide(s) may account for part of the DSIP-like immunoreactivity observed in tissue distribution studies

*Correspondence: Chuan Xiang, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Listen to this Article A review published in the Journal of Physiological Sciences discussed how the human body regulates satiety and food intake

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