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In addition, more people achieved these treatment thresholds, and the magnitude of HbA1c and body weight reductions was significantly greater with tirzepatide at the early time points of 4, 12, and 24 weeks after treatment initiation

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Receptor autophosphorylation, downstream phosphorylation of IRS-1 and Shc, and activation of PI3K and MAPK occur with similar kinetics to native IGF-1 once the ligand reaches the receptor

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p53-pS15 is a major focal point in p53 activation to mediate p53-dependent transcription or growth arrest, Ser 15 phosphorylation triggers a sequence of additional sites phosphorylation in p53 (including Ser9, -20, -46 and Thr18) that contribute further to p53 activation 28