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A 2025 review in Endocrinology found that endogenous sex hormones estrogen in particular modulate GLP-1 receptor expression in the hypothalamus, and that women experience both greater weight loss and higher rates of side effects than men on GLP-1 agonists

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10.1074/jbc.M115.678953 38 GagliardiM.CotellaD.SantoroC.CorD.BarlevN

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