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These samples were divided into a discovery set (n = 243) and a validation set (n = 82)

In 2019, the first oral GLP-1 medication, Rybelsus, became available

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Therefore, early-life gut microbiota-host interactions critically shape immunological trajectories by integrating microbial colonization, innate receptor signaling, and tolerance programming, forming an essential developmental axis for pulmonary and systemic immune homeostasis

Together, these enzymes create microenvironmental gradients of thyroid hormone signaling, tailoring activity to the specific demands of each brain region