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The real-world choice usually comes down to three questions: pill or injection

Nat Genet 49:1726 Gregg EW, Cheng YJ, Narayan KM et al (2007) The relative contributions of different levels of overweight and obesity to the increased prevalence of diabetes in the United States: 19762004

From 'Laughing Gas' to 'Galaxy Gas': An Updated Review on the Neurological, Pathologic, and Psychiatric Sequelae of Nitrous Oxide Abuse

And, it is

For a 5000 IU vial, 5 mL of water creates a concentration of 1000 IU per milliliter

This is why many patients don't realize their injection has degraded until they notice reduced weight loss or appetite-suppressing effects