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The CALERIE Research Group

Dose Group GI Adverse Events (%) Nausea (%) Abdominal Discomfort/Pain Placebo 32.6% 11.6% Low baseline 1 mg 48.6% ~20% Mild, infrequent 4 mg (escalated) 60.0% ~30% Moderate increase 8 mg (escalated) 57.5% ~38% Present in dose-escalation phase 12 mg (escalated) 66.7% 45.8% Highest incidence, mostly transient Source: Jastreboff AM, Kaplan LM, Fras JP, et al

Just imagine yourself but with ten to twenty per cent more energy, he said

Ribosome-inactivating proteins: current status and biomedical applications

doi: 10.3390/nu13082493

So, if you find yourself getting too wrapped up in the numbers and stressed about hitting your targets, it might be time to switch gears