(PubMed) Ebadi M, Montano-Loza AJ
Safety of L-Carnitine Carnitine is relatively well-tolerated but in high doses it may increase levels of trimethylamine-N-oxide (TMAO), a compound linked with an heart disease since it can increase blood pressure and the formation of plaque within the artery walls (atherosclerosis) (9)
An early trial in 160 men and women diagnosed with a recent MI showed that oral L-carnitine (4 g/day) in addition to standard pharmacological treatment for one year significantly reduced mortality and the occurrence of angina attacks compared to the control (47)
progressive cardiomyopathy, elevated creatine kinase, and skeletal myopathy in childhood
Nevertheless, the observations are interesting and have been subsequently followed up by a study that showed 12 weeks of daily carnitine and carbohydrate feeding in humans increases skeletal muscle total carnitine content and prevents body mass accrual associated with carbohydrate feeding alone (3)
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