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12 , 13 Opposite effects are observed in dysbiosis conditions (eg, a low Bacteroidetes to Firmicutes ratio), where high levels of lipopolysaccharides and pro-inflammatory cytokines (eg, interleukin-1, interleukin-6, tumor necrosis factor ) are produced by gut bacteria (Figure 1)

Lack of B12 can affect immune system

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There was no significant difference in the incidence of overcorrection between the two groups

However, preclinical studies demonstrate therapeutic effects with once-daily or even less frequent administration, suggesting tissue distribution, receptor binding, or cellular signaling effects extend beyond plasma clearance

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