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Tirzepatide produced substantially greater weight loss (~78% additional) and superior glycemic control (~0.8% additional HbA1c reduction), yet the additional cardiovascular benefit over an already-active comparator was modest

Furthermore, several modifications of GIP Tyr 1 that facilitate its insulinotropic activity 18 may also be considered

2020;19:e13050

Overall, glycines action is complex-spanning from central-nervous-system neurotransmission to peripheral-tissue biosynthesis-which underscores why glycine has been explored in contexts ranging from neurological disorders to wound healing

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