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RAS-targeted therapies: is the undruggable drugged

After the third decade of life, there is a progressive decline of GH secretion by approximately 15% for every decade of adult life (7)

Zhang YL, Hernandez-Ono A, Ko C, Yasunaga K, Huang LS, Ginsberg HN

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To keep both signals on the same short timescale and preserve natural GH pulsatility

This dramatic rise reflects updated clinical guidelines from the American Diabetes Association (ADA), which now recommend GLP-1 receptor agonists as first-line therapy for many patients