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The expressions of fibrosis markers TGF-, CTGF, and Smad 2/3 were significantly up-regulated in the BCNI group

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Confirmatory diagnostic studies should be performed prior to initiating therapy, if possible, and the patient should be followed with appropriate studies to demonstrate hematologic improvement (Hgb, hematocrit, RBC, reticulocyte count)

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This balanced activity suggests that DPDPE is capable of engaging conserved activation mechanisms shared between incretin receptors, despite differences in their primary sequence and ligand recognition features (Figure Xa)