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Glutathione is an antioxidant that protects the body from free radicals to support cellular function and homeostasis

The net reaction is as follows: 3 Glucose 6-phosphate + 6 NADP + + 5 NAD + + 5 P i + 8 ADP 5 Pyruvate + 3 CO 2 + 6 NADPH + 5 NADH + 8 ATP + 2 H 2 O + 8 H + If the cell requires additional ATP, the pyruvate produced can be further oxidized via the citric acid cycle

Khare et al., 2017)

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A cluster of patients with a chronic mononucleosis-like syndrome

[16] Targeted disruption of the mitochondrial GPX4 isoform (mGPX4) caused infertility in male mice and disruption of the nuclear GPX4 isoform (nGPX4) reduced the structural stability of sperm chromatin, yet both knockout mouse models (for mGPX4 and nGPX4) were fully viable