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As a synthetic 39-amino acid peptide, Retatrutide (LY3437943) acts as a single-sequence multi-agonist with structural affinity for three distinct metabolic receptors: Gastric Inhibitory Polypeptide (GIP), Glucagon-Like Peptide-1 (GLP-1), and Glucagon (GCGR)

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Ingrezza also outperformed placebo on secondary endpoints, including the Clinical Global Impression of Change and Patient Global Impression of Change response status