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N.AdhikariS.PathakS.et al (2025)
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The IgG Fc contains distinct Fc receptor (FcR) binding sites: the leukocyte receptors Fc gamma RI and Fc gamma RIIa bind to a region in the Fc distinct from that recognized by neonatal FcR and protein A
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Thus, a major concern is, of course, safety issues
Additionally, this approach is scalable to generate mini-liver organoids that contain vasculature while recapitulating the complexity of cell types associated with the liver
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