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No research program is without constraints, and acknowledging these limitations helps set appropriate expectations

Acknowledgements This work was supported by Chang Gung Memorial Hospital [CMRPG391311, CMRPG3A1131, CMRPG3H0611 and Grants CIRPD1D0071-3

In a recent prespecified analysis of the SELECT trial, participants with overweight or obesity and preexisting cardiovascular disease and prediabetes demonstrated increased reversion to normoglycemia and reduced progression to diabetes following long-term semaglutide treatment compared with placebo, although glycemic control deteriorated slightly over time at a similar rate between both groups [18]

Pharmacodynamic and pharmacokinetic parameters were dose-dependent

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If it shows up as low motivation, sleeping too much, lethargy, and mental slowing, that can point in another