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Discontinuation rates: Despite higher absolute side effect rates, discontinuation due to adverse events is similar between medications (approximately 5-7% in trials)

Of note, to reduce the generation of mitochondrial ROS or to increase the scavenge of ROS similarly attenuate mitochondrial oxidative stress and kidney injury (Li et al., 2021b)

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170 Misfolded proteins targeted by RNF5 include mutant CFTR, 119 solute carrier family 1 member 5 (SLC1A5), and SLC38A2