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Weeks 8 through 12: New normal By this point, your body has largely adapted
Weight loss during week one is typically 0-2 pounds
There are no deductibles, claim submissions, or back-and-forth with insurance companies
Switching to the oral small molecule glucagon-like peptide-1 (GLP-1) orforglipron after taking injectable GLP-1s helped patients maintain mostbut not allof their weight loss, according to a clinical trial led by Weill Cornell Medicine and NewYork-Presbyterian investigators
This reduction in heat-generating capacity and insulation leads to increased cold sensitivity, particularly in the extremities
For example, a patient managing hypertension may find that after six months on oral semaglutide, their weight loss allows them to reduce or even discontinue their blood pressure medications
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