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On the basis of microscopic reversibility of enzymatic reactions, the enzyme-catalyzed oxidation of roGFP2(SH) 2 by GSSG or GSSR follows the reverse reaction of mechanism (iii)

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Left untreated, such deficiencies may result in neurological symptoms, including numbness, tingling, and loss of balance

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In cases of diabetic nephropathy, chronic hyperglycemia induces the formation of autoantibodies against podocyte antigens, which cross-react with glomerular components, triggering complement activation and foot process effacement

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