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Together they increase cardiovascular strain, especially in patients with hypertension or arrhythmia history

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Many recent studies also focus on the metabolic aspects of depression, suggesting the involvement of peripheral and central impairments in energy homeostasis, mitochondrial dysfunction, as well as disturbances in the gut-brain axis and gut microbiota dysbiosis as noteworthy factors in the pathogenesis of depression [6,7,8,9]

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