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The transmembrane helices: Like any other G-protein coupled receptor, this protein has seven transmembrane helices (TM1-7) with surface exposed hydrophobic amino acids in the membrane region (see Figure 3b)

2 The spectrum of MASLD encompasses metabolic dysfunction-associated steatotic liver, metabolic dysfunction-associated steatohepatitis (MASH), liver fibrosis, and cirrhosis, representing a significant global public health threat

Renfree et al, 1992)

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It may also reflect a lack of perceived viable alternatives to lose weight: lifestyle interventions for weight management (even very intensive, well-designed, multicomponent ones) have a very modest impact on weight loss [47, 48]