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This increases the expression of major antioxidant systems, including GSH, glutathione peroxidase, glutathione S-transferases, thioredoxin (Trx), and thioredoxin reductase (TrxR)

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Functional assessments reveal cartilage generated by FOXO4-DRI-pretreated chondrocytes displays significantly lower senescence levels compared to cartilage from untreated cells