Females on SD had a slight body weight reduction compared to their starting weight, which was greater than the body-weight change seen in males on SD ( p = 0.022, Cohens d = 0.950)
Adverse Reactions/Side Effects The following adverse reactions are described in more detail in other sections of the prescribing information: Hypersensitivity reactions to sertraline [See Contraindications (4)] Disulfiram-alcohol reaction when ZOLOFT oral solution is taken with disulfiram [See Contraindications (4)] QTc prolongation and ventricular arrhythmias when taken with pimozide [See Contraindications (4), Clinical Pharmacology (12.2)] Suicidal thoughts and behaviors [See Warnings and Precautions (5.1)] Serotonin syndrome [See Contraindications (4), Warnings and Precautions (5.2), Drug Interactions (7.1)] Increased risk of bleeding [See Warnings and Precautions (5.3)] Activation of mania/hypomania [See Warnings and Precautions (5.4)] Discontinuation syndrome [See Warnings and Precautions (5.5)] Seizures [See Warnings and Precautions (5.6)] Angle-closure glaucoma [See Warnings and Precautions (5.7)] Hyponatremia [See Warnings and Precautions (5.8)] Sexual Dysfunction [See Warnings and Precautions (5.11)] 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice
Tirzepatide injections ($289/mo) offer dual GIP and GLP-1 receptor activation, producing 2025% greater weight loss than semaglutide alone in head-to-head trials, and may be a cost-effective alternative if higher efficacy justifies the modest price difference
Persistent anxiety suggests either a dose-related issue that needs adjustment, an underlying condition that needs treatment, or a psychological factor that needs professional support
Make sure any doctor or dentist who treats you knows you are using this medication, as it may affect the results of certain medical tests
Manolis et al
