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Propionate shows particularly high efficacy, and variations in the Firmicutes-to-Bacteroidetes ratio may meaningfully shape incretin responses independently of total SCFA levels

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Currently there are several small molecule agonists of GPR119 in clinical trials being tested for their efficacy in treating the hyperglycemia of type 2 diabetes as well as for their efficacy in treating obesity.

This action helps with appetite suppression, slows gastric emptying (the slower digestive process), and improves the bodys insulin response