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Anecdotal reports from research subjects and biohacking communities describe body composition improvements, increased subjective energy and mental clarity, and minimal side effects, though these uncontrolled observations require cautious interpretation and cannot substitute for rigorous clinical trials

Pros of brand-name GLP-1s Brand-name medications have a few key advantages: These drugs have been studied in large, high-quality clinical trials and shown to lower blood sugar, support weight loss, and reduce cardiovascular risk in people with type 2 diabetes

The cost-effectiveness of total spending depends on several factors: how many surgeries are avoided, the long-term cost of medications taken indefinitely and how many patients ultimately undergo both surgical and pharmacological treatments

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Table 1 (next page) summarises the major product launches from 2010 to 2023