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If side effects are troublesome, dose adjustments or discontinuation may be considered

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Early-onset alcohol use increased H3K27 trimethylation at amygdalar BDNF and Arc loci, correlating with decreased gene expression 42

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Targeting genes involved in DNA damage repair response including PARP, DNA-PKcs, ATR, ATM, CHK1, WEE1 might achieve unexpected clinical response in MM patients (162164)