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It is unknown whether Victoza causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans, as the human relevance of liraglutide-induced rodent thyroid C-cell tumors has not been determined Victoza is contraindicated in patients with a personal or family history of MTC and in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

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More extensively investigated was the -glutamyl conjugate of L-DOPA (dihydroxyphenylalanine)

[ Randomized controlled trial, general recommendation ] Key question Is achieving and maintaining a weight loss of more than 5% through MNT and exercise more effective in improving health outcomes for people with T2DM and obesity compared to a weight reduction of less than 5%