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Obesity is a major cause of morbidity and mortality in children and adolescents with this syndrome via deterioration of the POMC-MC4R anorectic pathways [7, 8]

In February 2022, Russia invaded Ukraine which has caused and could continue to cause significant market disruptions and volatility within the markets in Russia, Europe, and the United States

Marty et al ., Reference Marty, Farokhnia, Munier, Mulpuri, Leggio and Spigelman2020

Most of these studies have found use of SGLT2is to be cost-effective

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However, Wegovy (the same semaglutide molecule at weight-loss doses) is FDA-approved for chronic weight management