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Its consumption in small bowel mucosa exceeds the rate of production during catabolic stress such as trauma, sepsis and post surgery [1, 2]

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A registry study in 2020 in the US showed only 40% of the patients with CKD were on ACEi/ ARBs, and smaller similar percentages (around 6%) for SGLT2i and GLP1-RA use (Nicholas, et al, Diabetes Obes Metab, 2023)

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